SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.
mRNAs targeted by endonuclease decay generally disappear without detectable decay intermediates. The exception to this is nonsense-containing human β-globin mRNA, where the destabilization of full-length mRNA is accompanied by the cytoplasmic accumulation of 5'-truncated transcripts in erythroid cel...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science (PLoS)
2013-01-01
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| Serija: | PLoS ONE |
| Online pristup: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074791&type=printable |
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