Active-Site Mutations in the Xrn1p Exoribonuclease of Saccharomyces cerevisiae Reveal a Specific Role in Meiosis

Xrn1p of Saccharomyces cerevisiae is a major cytoplasmic RNA turnover exonuclease which is evolutionarily conserved from yeasts to mammals. Deletion of the XRN1 gene causes pleiotropic phenotypes, which have been interpreted as indirect consequences of the RNA turnover defect. By sequence comparison...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Solinger, Jachen A., Pascolini, Donatella, Heyer, Wolf-Dietrich
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1999
Soggetti:	Gene Expression
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84450/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10454540/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.9.5930
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