Stability of the Human Fragile X (CGG)(n) Triplet Repeat Array in Saccharomyces cerevisiae Deficient in Aspects of DNA Metabolism

Expanded trinucleotide repeats underlie a growing number of human diseases. The human FMR1 (CGG)(n) array can exhibit genetic instability characterized by progressive expansion over several generations leading to gene silencing and the development of the fragile X syndrome. While expansion is depend...

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Bibliographic Details
Main Authors: White, Peter J., Borts, Rhona H., Hirst, Mark C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
DNA Dynamics and Chromosome Structure
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84419/
https://ncbi.nlm.nih.gov/pubmed/10409756
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