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Stability of the Human Fragile X (CGG)(n) Triplet Repeat Array in Saccharomyces cerevisiae Deficient in Aspects of DNA Metabolism

Expanded trinucleotide repeats underlie a growing number of human diseases. The human FMR1 (CGG)(n) array can exhibit genetic instability characterized by progressive expansion over several generations leading to gene silencing and the development of the fragile X syndrome. While expansion is depend...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: White, Peter J., Borts, Rhona H., Hirst, Mark C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 1999
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC84419/
https://ncbi.nlm.nih.gov/pubmed/10409756
Tagiau: Ychwanegu Tag
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