Assembly of the Cleavage and Polyadenylation Apparatus Requires About 10 Seconds In Vivo and Is Faster for Strong than for Weak Poly(A) Sites

We have devised a cis-antisense rescue assay of cleavage and polyadenylation to determine how long it takes the simian virus 40 (SV40) early poly(A) signal to commit itself to processing in vivo. An inverted copy of the poly(A) signal placed immediately downstream of the authentic one inhibited proc...

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Bibliographic Details
Main Authors: Chao, Lily C., Jamil, Amer, Kim, Steven J., Huang, Lisa, Martinson, Harold G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84411/
https://ncbi.nlm.nih.gov/pubmed/10409748
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