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Role of poly(A) polymerase in the cleavage and polyadenylation of mRNA precursor.

To determine the role of poly(A) polymerase in 3'-end processing of mRNA, the effect of purified poly(A) polymerase antibodies on endonucleolytic cleavage and polyadenylation was studied in HeLa nuclear extracts, using adenovirus L3 pre-mRNA as the substrate. Both Mg2+- and Mn2+-dependent reactions...

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Publicat a:Mol Cell Biol
Autors principals: Terns, M P, Jacob, S T
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1989
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362560/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2566910/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.4.1435-1444.1989
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