B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway

Growth factor-dependent kinases, such as phosphatidylinositol 3-kinase (PI 3-kinase) and Raf kinases, have been implicated in the suppression of apoptosis. We have recently established Rat-1 fibroblast cell lines overexpressing B-Raf, leading to activation of the MEK/Erk mitogen-activated protein ki...

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Bibliographic Details
Main Authors: Erhardt, Peter, Schremser, Erin J., Cooper, Geoffrey M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84374/
https://ncbi.nlm.nih.gov/pubmed/10409722
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