PIC-1/SUMO-1-Modified PML-Retinoic Acid Receptor α Mediates Arsenic Trioxide-Induced Apoptosis in Acute Promyelocytic Leukemia

Fusion proteins involving the retinoic acid receptor α (RARα) and PML or PLZF nuclear protein are the genetic markers of acute promyelocytic leukemia (APL). APLs with PML-RARα or PLZF-RARα fusion protein differ only in their response to retinoic acid (RA) treatment: the t(15;17) (PML-RARα-positive)...

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Autors principals: Sternsdorf, Thomas, Puccetti, Elena, Jensen, Kirsten, Hoelzer, Dieter, Will, Hans, Ottmann, Oliver Gerhard, Ruthardt, Martin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC84360/
https://ncbi.nlm.nih.gov/pubmed/10373566
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