Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient Mice

The gene most commonly activated by chromosomal rearrangements in patients with T-cell acute lymphoblastic leukemia (T-ALL) is SCL/tal. In collaboration with LMO1 or LMO2, the thymic expression of SCL/tal leads to T-ALL at a young age with a high degree of penetrance in transgenic mice. We now show...

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Bibliographic Details
Main Authors: Chervinsky, David S., Zhao, Xian-Feng, Lam, Du H., Ellsworth, MaryKay, Gross, Kenneth W., Aplan, Peter D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84335/
https://ncbi.nlm.nih.gov/pubmed/10373552
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