Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient Mice

The gene most commonly activated by chromosomal rearrangements in patients with T-cell acute lymphoblastic leukemia (T-ALL) is SCL/tal. In collaboration with LMO1 or LMO2, the thymic expression of SCL/tal leads to T-ALL at a young age with a high degree of penetrance in transgenic mice. We now show...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Chervinsky, David S., Zhao, Xian-Feng, Lam, Du H., Ellsworth, MaryKay, Gross, Kenneth W., Aplan, Peter D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84335/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10373552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.7.5025
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