Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.

The LMO2 and TAL1 genes were first identified via chromosomal translocations and later found to encode proteins that interact during normal erythroid development. Some T cell leukaemia patients have chromosomal abnormalities involving both genes, implying that LMO2 and TAL1 act synergistically to pr...

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Autores principales: Larson, R C, Lavenir, I, Larson, T A, Baer, R, Warren, A J, Wadman, I, Nottage, K, Rabbitts, T H
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC449997/
https://ncbi.nlm.nih.gov/pubmed/8605871
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