Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span in Saccharomyces cerevisiae

A cause of aging in Saccharomyces cerevisiae is the accumulation of extrachromosomal ribosomal DNA circles (ERCs). Introduction of an ERC into young mother cells shortens life span and accelerates the onset of age-associated sterility. It is important to understand the process by which ERCs are gene...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Park, Peter U., Defossez, Pierre-Antoine, Guarente, Leonard
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1999
Schlagworte:	DNA Dynamics and Chromosome Structure
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84236/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10207108/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.5.3848
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