Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span in Saccharomyces cerevisiae

A cause of aging in Saccharomyces cerevisiae is the accumulation of extrachromosomal ribosomal DNA circles (ERCs). Introduction of an ERC into young mother cells shortens life span and accelerates the onset of age-associated sterility. It is important to understand the process by which ERCs are gene...

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Библиографические подробности

Опубликовано в::	Mol Cell Biol
Главные авторы:	Park, Peter U., Defossez, Pierre-Antoine, Guarente, Leonard
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 1999
Предметы:	DNA Dynamics and Chromosome Structure
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84236/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10207108/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.5.3848
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