Roles of the “Dispensable” Portions of RAG-1 and RAG-2 in V(D)J Recombination

V(D)J recombination is initiated by introduction of site-specific double-stranded DNA breaks by the RAG-1 and RAG-2 proteins. The broken DNA ends are then joined by the cellular double-strand break repair machinery. Previous work has shown that truncated (core) versions of the RAG proteins can catal...

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Main Authors: Steen, S. B., Han, J.-O., Mundy, C., Oettinger, M. A., Roth, D. B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84095/
https://ncbi.nlm.nih.gov/pubmed/10082568
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