CD5 Negatively Regulates the T-Cell Antigen Receptor Signal Transduction Pathway: Involvement of SH2-Containing Phosphotyrosine Phosphatase SHP-1

The negative regulation of T- or B-cell antigen receptor signaling by CD5 was proposed based on studies of thymocytes and peritoneal B-1a cells from CD5-deficient mice. Here, we show that CD5 is constitutively associated with phosphotyrosine phosphatase activity in Jurkat T cells. CD5 was found asso...

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Bibliografiska uppgifter
Huvudupphovsmän: Perez-Villar, Juan J., Whitney, Gena S., Bowen, Michael A., Hewgill, Derek H., Aruffo, Alejandro A., Kanner, Steven B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 1999
Ämnen:
Cell Growth and Development
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC84084/
https://ncbi.nlm.nih.gov/pubmed/10082557
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