Conserved Loop I of U5 Small Nuclear RNA Is Dispensable for Both Catalytic Steps of Pre-mRNA Splicing in HeLa Nuclear Extracts

The function of conserved regions of the metazoan U5 snRNA was investigated by reconstituting U5 small nuclear ribonucleoprotein particles (snRNPs) from purified snRNP proteins and HeLa or Xenopus U5 snRNA mutants and testing their ability to restore splicing to U5-depleted nuclear extracts. Substit...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Ségault, Véronique, Will, Cindy L., Polycarpou-Schwarz, Maria, Mattaj, Iain W., Branlant, Christiane, Lührmann, Reinhard
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1999
Schlagworte:	Gene Expression
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84071/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10082544/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.4.2782
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