Synergism with Germ Line Transcription Factor Oct-4: Viral Oncoproteins Share the Ability To Mimic a Stem Cell-Specific Activity

Activation of transcription by Oct-4 from remote binding sites requires a cofactor that is restricted to embryonal stem cells. The adenovirus E1A protein can mimic the activity of this stem cell-specific factor and stimulates Oct-4 activity in differentiated cells. Here we characterize the Oct-4–E1A...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Brehm, A., Ohbo, K., Zwerschke, W., Botquin, V., Jansen-Dürr, P., Schöler, H. R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84056/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10082529/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.4.2635
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