Synergism with Germ Line Transcription Factor Oct-4: Viral Oncoproteins Share the Ability To Mimic a Stem Cell-Specific Activity

Activation of transcription by Oct-4 from remote binding sites requires a cofactor that is restricted to embryonal stem cells. The adenovirus E1A protein can mimic the activity of this stem cell-specific factor and stimulates Oct-4 activity in differentiated cells. Here we characterize the Oct-4–E1A...

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Main Authors: Brehm, A., Ohbo, K., Zwerschke, W., Botquin, V., Jansen-Dürr, P., Schöler, H. R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84056/
https://ncbi.nlm.nih.gov/pubmed/10082529
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