Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts

The irreversible G(1) arrest in senescent human diploid fibroblasts is probably caused by inactivation of the G(1) cyclin–cyclin-dependent kinase (Cdk) complexes responsible for phosphorylation of the retinoblastoma protein (pRb). We show that the Cdk inhibitor p21(Sdi1,Cip1,Waf1), which accumulates...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Stein, Gretchen H., Drullinger, Linda F., Soulard, Alexandre, Dulić, Vjekoslav
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84004/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022898/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.2109
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