Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts

The irreversible G(1) arrest in senescent human diploid fibroblasts is probably caused by inactivation of the G(1) cyclin–cyclin-dependent kinase (Cdk) complexes responsible for phosphorylation of the retinoblastoma protein (pRb). We show that the Cdk inhibitor p21(Sdi1,Cip1,Waf1), which accumulates...

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Библиографические подробности
Главные авторы: Stein, Gretchen H., Drullinger, Linda F., Soulard, Alexandre, Dulić, Vjekoslav
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 1999
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC84004/
https://ncbi.nlm.nih.gov/pubmed/10022898
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