Substrate Specificities of SR Proteins in Constitutive Splicing Are Determined by Their RNA Recognition Motifs and Composite Pre-mRNA Exonic Elements

We report striking differences in the substrate specificities of two human SR proteins, SF2/ASF and SC35, in constitutive splicing. β-Globin pre-mRNA (exons 1 and 2) is spliced indiscriminately with either SR protein. Human immunodeficiency virus tat pre-mRNA (exons 2 and 3) and immunoglobulin μ-cha...

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Main Authors: Mayeda, Akila, Screaton, Gavin R., Chandler, Sharon D., Fu, Xiang-Dong, Krainer, Adrian R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC83978/
https://ncbi.nlm.nih.gov/pubmed/10022872
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