Substrate Specificities of SR Proteins in Constitutive Splicing Are Determined by Their RNA Recognition Motifs and Composite Pre-mRNA Exonic Elements

We report striking differences in the substrate specificities of two human SR proteins, SF2/ASF and SC35, in constitutive splicing. β-Globin pre-mRNA (exons 1 and 2) is spliced indiscriminately with either SR protein. Human immunodeficiency virus tat pre-mRNA (exons 2 and 3) and immunoglobulin μ-cha...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Mayeda, Akila, Screaton, Gavin R., Chandler, Sharon D., Fu, Xiang-Dong, Krainer, Adrian R.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1999
Materias:	Gene Expression
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83978/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.1853
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