A Premature Termination Codon Interferes with the Nuclear Function of an Exon Splicing Enhancer in an Open Reading Frame-Dependent Manner

Premature translation termination codon (PTC)-mediated effects on nuclear RNA processing have been shown to be associated with a number of human genetic diseases; however, how these PTCs mediate such effects in the nucleus is unclear. A PTC at nucleotide (nt) 2018 that lies adjacent to the 5′ elemen...

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Bibliographic Details
Main Authors: Gersappe, Anand, Pintel, David J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC83958/
https://ncbi.nlm.nih.gov/pubmed/10022852
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