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A Premature Termination Codon Interferes with the Nuclear Function of an Exon Splicing Enhancer in an Open Reading Frame-Dependent Manner

Premature translation termination codon (PTC)-mediated effects on nuclear RNA processing have been shown to be associated with a number of human genetic diseases; however, how these PTCs mediate such effects in the nucleus is unclear. A PTC at nucleotide (nt) 2018 that lies adjacent to the 5′ elemen...

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Pubblicato in:Mol Cell Biol
Autori principali: Gersappe, Anand, Pintel, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 1999
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83958/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022852/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.1640
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