Cyclosporin A Promotes Translational Silencing of Autocrine Interleukin-3 via Ribosome-Associated Deadenylation

Translation is regulated predominantly by an interplay between cis elements at the 3′ and 5′ ends of mRNAs and trans-acting proteins. Cyclosporin A (CsA), a calcineurin antagonist and blocker of interleukin-2 (IL-2) transcription in T cells, was found to inhibit translation of IL-3 mRNA in autocrine...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Nair, Asha P. K., Hirsch, Hans H., Colombi, Marco, Moroni, Christoph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83946/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9858612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.1.889
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