Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region.

We analyzed the effect of rapamycin on autocrine mast cell tumor lines with abnormally stable interleukin-3 (IL-3) transcripts due to a defect in mRNA degradation. Rapamycin inhibited IL-3 mRNA expression specifically, while transcripts of IL-4 and IL-6 were not affected. As indicated by the use of...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Banholzer, R, Nair, A P, Hirsch, H H, Ming, X F, Moroni, C
פורמט: Artigo
שפה:Inglês
יצא לאור: 1997
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC232178/
https://ncbi.nlm.nih.gov/pubmed/9154824
תגים: הוספת תג
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