Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3' untranslated region.

We analyzed the effect of rapamycin on autocrine mast cell tumor lines with abnormally stable interleukin-3 (IL-3) transcripts due to a defect in mRNA degradation. Rapamycin inhibited IL-3 mRNA expression specifically, while transcripts of IL-4 and IL-6 were not affected. As indicated by the use of...

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Publicado en:	Mol Cell Biol
Autores principales:	Banholzer, R, Nair, A P, Hirsch, H H, Ming, X F, Moroni, C
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC232178/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9154824/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.17.6.3254
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