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Regulation of Cyclin A-Cdk2 by SCF Component Skp1 and F-Box Protein Skp2

Cyclin A-Cdk2 complexes bind to Skp1 and Skp2 during S phase, but the function of Skp1 and Skp2 is unclear. Skp1, together with F-box proteins like Skp2, are part of ubiquitin-ligase E3 complexes that target many cell cycle regulators for ubiquitination-mediated proteolysis. In this study, we invest...

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Publicado no:Mol Cell Biol
Principais autores: Yam, Cain H., Ng, Raymond W. M., Yi Siu, Wai, Lau, Anita W. S., Poon, Randy Y. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1999
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83921/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9858587/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.1.635
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