Transcriptional and Posttranscriptional Silencing of Rodent α1(I) Collagen by a Homologous Transcriptionally Self-Silenced Transgene

Transient transfection of rodent fibroblasts with plasmids carrying a full-size pro-α1(I) collagen gene (pWTC1) results in rapid reduction of the endogenous transcripts by >90%, while the transgene mRNA is undetectable. Using deletion constructs, two adjacent 5′ noncoding regions of the gene are ide...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Bahramian, Mohammad B., Zarbl, Helmut
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1999
Soggetti:	Gene Expression
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9858551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.1.274
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