Transcriptional and Posttranscriptional Silencing of Rodent α1(I) Collagen by a Homologous Transcriptionally Self-Silenced Transgene
Transient transfection of rodent fibroblasts with plasmids carrying a full-size pro-α1(I) collagen gene (pWTC1) results in rapid reduction of the endogenous transcripts by >90%, while the transgene mRNA is undetectable. Using deletion constructs, two adjacent 5′ noncoding regions of the gene are ide...
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| Publicat a: | Mol Cell Biol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Taylor & Francis
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83885/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9858551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.1.274 |
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