A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice

Metabolic endotoxemia has been suggested to play a role in the pathophysiology of metaflammation, insulin-resistance and ultimately type-2 diabetes mellitus (T2DM). The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37, in T2DM is unknown. We report here for the first...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Mohammad, Shireen, Al Zoubi, Sura, Collotta, Debora, Krieg, Nadine, Wissuwa, Bianka, Ferreira Alves, Gustavo, Purvis, Gareth S. D., Norata, Giuseppe Danilo, Baragetti, Andrea, Catapano, Alberico Luigi, Solito, Egle, Zechendorf, Elisabeth, Schürholz, Tobias, Correa-Vargas, Wilmar, Brandenburg, Klaus, Coldewey, Sina M., Collino, Massimo, Yaqoob, Muhammad M., Martin, Lukas, Thiemermann, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8328475/
https://ncbi.nlm.nih.gov/pubmed/34349763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.701275
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