Newly Identified Chemicals Preserve Mitochondrial Capacity and Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models

Purpose: Metabolic stress and associated mitochondrial dysfunction are implicated in retinal degeneration irrespective of the underlying cause. We identified seven unique chemicals from a Chembridge DiverSET screen and tested their protection against photoreceptor cell death in cell- and animal-base...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Ocul Pharmacol Ther
Prif Awduron: Beeson, Craig, Peterson, Yuri K., Perron, Nathan, Bandyopadhyay, Mausumi, Nasarre, Cecile, Beeson, Gyda, Comer, Richard F., Lindsey, Christopher C., Schnellmann, Rick G., Rohrer, Bärbel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Mary Ann Liebert, Inc., publishers 2021
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8328042/
https://ncbi.nlm.nih.gov/pubmed/33945330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jop.2020.0140
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