SAHA is neuroprotective in in vitro and in situ models of retinitis pigmentosa

Purpose: Recent reports linking HDAC6 to mitochondrial turnover and neurodegeneration led us to hypothesize that an inhibitor such as Vorinostat (suberoylanilide hydroxamic acid, SAHA) may reduce mitochondrial damage found in retinitis pigmentosa (RP), a progressive neurodegenerative disease of the...

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Udgivet i:Mol Vis
Main Authors: Perron, Nathan R., Nasarre, Cécile, Bandyopadhyay, Mausumi, Beeson, Craig C., Rohrer, Baerbel
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Vision 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056468/
https://ncbi.nlm.nih.gov/pubmed/33907370
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