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Radiotherapy Delivered before CDK4/6 Inhibitors Mediates Superior Therapeutic Effects in ER(+) Breast Cancer

PURPOSE: Recent preclinical data suggest that cyclin-dependent kinase 4/6 (CDK4/6) inhibition may be harnessed to sensitize estrogen receptor–positive (ER(+)) breast cancer to radiotherapy. However, these findings were obtained in human ER(+) breast cancer cell lines exposed to subclinical doses of...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Petroni, Giulia, Buqué, Aitziber, Yamazaki, Takahiro, Bloy, Norma, Di Liberto, Maurizio, Chen-Kiang, Selina, Formenti, Silvia C., Galluzzi, Lorenzo
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327758/
https://ncbi.nlm.nih.gov/pubmed/33495311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-3871
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