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MUC16 suppresses human and murine innate immune responses

OBJECTIVE: MUC16, the mucin that contains the CA125 epitopes, suppresses the cytolytic responses of human NK cells and inhibits the efficacy of therapeutic antibodies. Here, we provide further evidence of the regulatory role of MUC16 on human and murine NK cells and macrophages. METHODS. Target cell...

詳細記述

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書誌詳細
出版年:Gynecol Oncol
主要な著者: Felder, Mildred, Kapur, Arvinder, Rakhmilevich, Alexander L., Qu, Xiaoyi, Sondel, Paul M., Gillies, Stephen D., Connor, Joseph, Patankar, Manish S.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327469/
https://ncbi.nlm.nih.gov/pubmed/30626487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2018.12.023
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