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The Aryl Hydrocarbon Receptor Activates Ceramide Biosynthesis in Mice Contributing to Hepatic Lipogenesis
Aryl hydrocarbon receptor (AHR) activation via 2,3,7,8-tetrachlorodibenzofuran (TCDF) induces the accumulation of hepatic lipids. Here we report that AHR activation by TCDF (24 μg/kg body weight given orally for five days) induced significant elevation of hepatic lipids including ceramides in mice,...
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| Veröffentlicht in: | Toxicology |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8327397/ https://ncbi.nlm.nih.gov/pubmed/34097992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2021.152831 |
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