The Aryl Hydrocarbon Receptor Activates Ceramide Biosynthesis in Mice Contributing to Hepatic Lipogenesis

Aryl hydrocarbon receptor (AHR) activation via 2,3,7,8-tetrachlorodibenzofuran (TCDF) induces the accumulation of hepatic lipids. Here we report that AHR activation by TCDF (24 μg/kg body weight given orally for five days) induced significant elevation of hepatic lipids including ceramides in mice,...

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Detalhes bibliográficos
Publicado no:Toxicology
Main Authors: Liu, Qing, Zhang, Limin, Allman, Erik L., Hubbard, Troy D., Murray, Iain A., Hao, Fuhua, Tian, Yuan, Gui, Wei, Nichols, Robert G., Smith, Philip B., Anitha, Mallappa, Perdew, Gary H., Patterson, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327397/
https://ncbi.nlm.nih.gov/pubmed/34097992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2021.152831
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