A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise

Brain-derived neurotrophic factor (Bdnf) expression is tightly controlled at the transcriptional and post-transcriptional levels. Previously, we showed that inhibition of noncoding Bdnf antisense (Bdnf-AS) RNA upregulates Bdnf protein. Here, we generated a Bdnf-antisense knockout (Bdnf-AS KO) mouse...

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Veröffentlicht in:Heliyon
Hauptverfasser: Modarresi, Farzaneh, Pedram Fatemi, Roya, Razavipour, Seyedeh Fatemeh, Ricciardi, Natalie, Makhmutova, Madina, Khoury, Nathalie, Magistri, Marco, Volmar, Claude-Henry, Wahlestedt, Claes, Faghihi, Mohammad Ali
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327352/
https://ncbi.nlm.nih.gov/pubmed/34377851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2021.e07570
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