The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by well-defined neuropathological brain changes including amyloid plaques, neurofibrillary tangles and the presence of chronic neuroinflammation. Objective: The brain penetrant BET bromodomain inhibitor JQ1 has been sh...

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Bibliographic Details
Published in:Curr Alzheimer Res
Main Authors: Magistri, Marco, Velmeshev, Dmitry, Makhmutova, Madina, Patel, Prutha, Sartor, Gregory C., Volmar, Claude-Henry, Wahlestedt, Claes, Faghihi, Mohammad Ali
Format: Artigo
Language:Inglês
Published: Bentham Science Publishers 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026248/
https://ncbi.nlm.nih.gov/pubmed/27117003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1567205013666160427101832
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