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Natural Antisense Inhibition Results in Transcriptional De-Repression and Gene Upregulation
Here we demonstrate that natural antisense transcripts (NATs), which are abundant in mammalian genomes, can function as repressors of specific genomic loci and that their removal or inhibition by AntagoNAT oligonucleotides leads to transient and reversible upregulation of sense gene expression. As o...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144683/ https://ncbi.nlm.nih.gov/pubmed/22446693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2158 |
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