Natural Antisense Inhibition Results in Transcriptional De-Repression and Gene Upregulation

Here we demonstrate that natural antisense transcripts (NATs), which are abundant in mammalian genomes, can function as repressors of specific genomic loci and that their removal or inhibition by AntagoNAT oligonucleotides leads to transient and reversible upregulation of sense gene expression. As o...

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Detaylı Bibliyografya
Asıl Yazarlar: Modarresi, Farzaneh, Faghihi, Mohammad Ali, Lopez-Toledano, Miguel A., Fatemi, Roya Pedram, Magistri, Marco, Brothers, Shaun P., van der Brug, Marcel P., Wahlestedt, Claes
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144683/
https://ncbi.nlm.nih.gov/pubmed/22446693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2158
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