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An allosteric redox switch in domain V of β(2)-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition
β(2)-glycoprotein I (β(2)GPI) is an abundant multidomain plasma protein that plays various roles in the clotting and complement cascades. It is also the main target of antiphospholipid antibodies (aPL) in the acquired coagulopathy known as antiphospholipid syndrome (APS). Previous studies have shown...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8326733/ https://ncbi.nlm.nih.gov/pubmed/34197876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100890 |
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