An allosteric redox switch in domain V of β(2)-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition

β(2)-glycoprotein I (β(2)GPI) is an abundant multidomain plasma protein that plays various roles in the clotting and complement cascades. It is also the main target of antiphospholipid antibodies (aPL) in the acquired coagulopathy known as antiphospholipid syndrome (APS). Previous studies have shown...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Kumar, Suresh, Chinnaraj, Mathivanan, Planer, William, Zuo, Xiaobing, Macor, Paolo, Tedesco, Francesco, Pozzi, Nicola
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326733/
https://ncbi.nlm.nih.gov/pubmed/34197876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100890
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