The J-elongated conformation of β(2)-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome

β(2)-Glycoprotein I (β(2)GPI) is an abundant plasma protein displaying phospholipid-binding properties. Because it binds phospholipids, it is a target of antiphospholipid antibodies (aPLs) in antiphospholipid syndrome (APS), a life-threatening autoimmune thrombotic disease. Indeed, aPLs prefer membr...

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Udgivet i:J Biol Chem
Main Authors: Ruben, Eliza, Planer, William, Chinnaraj, Mathivanan, Chen, Zhiwei, Zuo, Xiaobing, Pengo, Vittorio, De Filippis, Vincenzo, Alluri, Ravi K., McCrae, Keith R., Macor, Paolo, Tedesco, Francesco, Pozzi, Nicola
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397106/
https://ncbi.nlm.nih.gov/pubmed/32518155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013939
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