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Characterization of newly established Pralatrexate-resistant cell lines and the mechanisms of resistance

BACKGROUND: Pralatrexate (PDX) is a novel antifolate approved for the treatment of patients with relapsed/refractory peripheral T-cell lymphoma, but some patients exhibit intrinsic resistance or develop acquired resistance. Here, we evaluated the mechanisms underlying acquired resistance to PDX and...

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Foilsithe in:BMC Cancer
Main Authors: Oiwa, Kana, Hosono, Naoko, Nishi, Rie, Scotto, Luigi, O’Connor, Owen A., Yamauchi, Takahiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325835/
https://ncbi.nlm.nih.gov/pubmed/34332580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-08607-9
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