Combined PET and whole-tissue imaging of lymphatic-targeting vaccines in non-human primates

Antigen accumulation in lymph nodes (LNs) is critical for vaccine efficacy, but understanding of vaccine biodistribution in humans or large animals remains limited. Using the rhesus macaque model, we employed a combination of positron emission tomography (PET) and fluorescence imaging to characteriz...

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Publié dans:Biomaterials
Auteurs principaux: Martin, Jacob T., Hartwell, Brittany L., Kumarapperuma, Sidath C., Melo, Mariane B., Carnathan, Diane G., Cossette, Benjamin J., Adams, Josetta, Gong, Siqi, Zhang, Wei, Tokatlian, Talar, Menis, Sergey, Schiffner, Torben, Franklin, Crystal G., Goins, Beth, Fox, Peter T., Silvestri, Guido, Schief, William R., Ruprecht, Ruth M., Irvine, Darrell J.
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325633/
https://ncbi.nlm.nih.gov/pubmed/34091299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2021.120868
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