RNA m(6)A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability

The molecular basis underlying the interaction between retrotransposable elements (RTEs) and the human genome remains poorly understood. Here, we profiled N(6)-methyladenosine (m(6)A) deposition on nascent RNAs in human cells by developing a new method MINT-Seq, which revealed that many classes of R...

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Pubblicato in:Cell Res
Autori principali: Xiong, Feng, Wang, Ruoyu, Lee, Joo-Hyung, Li, Shenglan, Chen, Shin-Fu, Liao, Zian, Hasani, Lana Al, Nguyen, Phuoc T., Zhu, Xiaoyu, Krakowiak, Joanna, Lee, Dung-Fang, Han, Leng, Tsai, Kuang-Lei, Liu, Ying, Li, Wenbo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Singapore 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324889/
https://ncbi.nlm.nih.gov/pubmed/34108665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-021-00515-8
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