Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells

COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients. Differences in the type and degree of inflammation appear to determine the severity of the disease. Recent reports show an increase in circulating monocytic-myeloid-derived suppressor cells (M-MDSC) in severe COVID 19 th...

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Udgivet i:Front Immunol
Main Authors: Dean, Matthew J., Ochoa, Juan B., Sanchez-Pino, Maria Dulfary, Zabaleta, Jovanny, Garai, Jone, Del Valle, Luis, Wyczechowska, Dorota, Baiamonte, Lyndsey Buckner, Philbrook, Phaethon, Majumder, Rinku, Vander Heide, Richard S., Dunkenberger, Logan, Thylur, Ramesh Puttalingaiah, Nossaman, Bobby, Roberts, W. Mark, Chapple, Andrew G., Wu, Jiande, Hicks, Chindo, Collins, Jack, Luke, Brian, Johnson, Randall, Koul, Hari K., Rees, Chris A., Morris, Claudia R., Garcia-Diaz, Julia, Ochoa, Augusto C.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324422/
https://ncbi.nlm.nih.gov/pubmed/34341659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.695972
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