Severe COVID-19 Is Characterized by an Impaired Type I Interferon Response and Elevated Levels of Arginase Producing Granulocytic Myeloid Derived Suppressor Cells

COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients. Differences in the type and degree of inflammation appear to determine the severity of the disease. Recent reports show an increase in circulating monocytic-myeloid-derived suppressor cells (M-MDSC) in severe COVID 19 th...

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Vydáno v:Front Immunol
Hlavní autoři: Dean, Matthew J., Ochoa, Juan B., Sanchez-Pino, Maria Dulfary, Zabaleta, Jovanny, Garai, Jone, Del Valle, Luis, Wyczechowska, Dorota, Baiamonte, Lyndsey Buckner, Philbrook, Phaethon, Majumder, Rinku, Vander Heide, Richard S., Dunkenberger, Logan, Thylur, Ramesh Puttalingaiah, Nossaman, Bobby, Roberts, W. Mark, Chapple, Andrew G., Wu, Jiande, Hicks, Chindo, Collins, Jack, Luke, Brian, Johnson, Randall, Koul, Hari K., Rees, Chris A., Morris, Claudia R., Garcia-Diaz, Julia, Ochoa, Augusto C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324422/
https://ncbi.nlm.nih.gov/pubmed/34341659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.695972
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