Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Here we confirmed pervasive phenotypic, functional, and transcriptional diff...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Immunol
Hlavní autoři: Tonnerre, Pierre, Wolski, David, Subudhi, Sonu, Al-Jabban, Jihad, Hoogeveen, Ruben C., Damasio, Marcos, Drescher, Hannah K., Bartsch, Lea M., Tully, Damien C., Sen, Debattama R., Bean, David J., Brown, Joelle, Torres-Cornejo, Almudena, Robidoux, Maxwell, Kvistad, Daniel, Alatrakchi, Nadia, Cui, Ang, Lieb, David, Cheney, James A., Gustafson, Jenna, Lewis-Ximenez, Lia L, Massenet-Regad, Lucile, Eisenhaure, Thomas, Aneja, Jasneet, Haining, W. Nicholas, Chung, Raymond T., Hacohen, Nir, Allen, Todd M., Kim, Arthur Y., Lauer, Georg M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323980/
https://ncbi.nlm.nih.gov/pubmed/34312544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00982-6
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky