Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques

Broadly neutralizing antibodies (bNAbs) directed to HIV-1 have shown promise at suppressing viremia in animal models. However, the use of bNAbs for the central nervous system (CNS) infection is confounded by poor penetration of the blood brain barrier (BBB). Typically, antibody concentrations in the...

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Detaylı Bibliyografya
Yayımlandı:PLoS Pathog
Asıl Yazarlar: Wen, Jing, Cheever, Tracy, Wang, Lan, Wu, Di, Reed, Jason, Mascola, John, Chen, Xuejun, Liu, Cuiping, Pegu, Amarendra, Sacha, Jonah B., Lu, Yunfeng, Haigwood, Nancy L., Chen, Irvin S. Y.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2021
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323878/
https://ncbi.nlm.nih.gov/pubmed/34283885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009738
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