Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques

Broadly neutralizing antibodies (bNAbs) directed to HIV-1 have shown promise at suppressing viremia in animal models. However, the use of bNAbs for the central nervous system (CNS) infection is confounded by poor penetration of the blood brain barrier (BBB). Typically, antibody concentrations in the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Pathog
Egile Nagusiak: Wen, Jing, Cheever, Tracy, Wang, Lan, Wu, Di, Reed, Jason, Mascola, John, Chen, Xuejun, Liu, Cuiping, Pegu, Amarendra, Sacha, Jonah B., Lu, Yunfeng, Haigwood, Nancy L., Chen, Irvin S. Y.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8323878/
https://ncbi.nlm.nih.gov/pubmed/34283885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009738
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