Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in newborn macaques

Prevention of mother to child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested anti-HIV-1 human neutralizing monoclonal antibodies (NmAb) as post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaq...

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Publicado no:Nat Med
Main Authors: Hessell, Ann J., Jaworski, J. Pablo, Epson, Erin, Matsuda, Kenta, Pandey, Shilpi, Kahl, Christoph, Reed, Jason, Sutton, William F., Hammond, Katherine B., Cheever, Tracy A., Barnette, Philip T., Legasse, Alfred W., Planer, Shannon, Stanton, Jeffrey J., Pegu, Amarendra, Chen, Xuejun, Wang, Keyun, Siess, Don, Burke, David, Park, Byung S., Axthelm, Michael K., Lewis, Anne, Hirsch, Vanessa M., Graham, Barney S., Mascola, John R., Sacha, Jonah B., Haigwood, Nancy L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983100/
https://ncbi.nlm.nih.gov/pubmed/26998834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4063
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