Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in newborn macaques

Prevention of mother to child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested anti-HIV-1 human neutralizing monoclonal antibodies (NmAb) as post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaq...

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發表在:Nat Med
Main Authors: Hessell, Ann J., Jaworski, J. Pablo, Epson, Erin, Matsuda, Kenta, Pandey, Shilpi, Kahl, Christoph, Reed, Jason, Sutton, William F., Hammond, Katherine B., Cheever, Tracy A., Barnette, Philip T., Legasse, Alfred W., Planer, Shannon, Stanton, Jeffrey J., Pegu, Amarendra, Chen, Xuejun, Wang, Keyun, Siess, Don, Burke, David, Park, Byung S., Axthelm, Michael K., Lewis, Anne, Hirsch, Vanessa M., Graham, Barney S., Mascola, John R., Sacha, Jonah B., Haigwood, Nancy L.
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983100/
https://ncbi.nlm.nih.gov/pubmed/26998834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4063
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